First results from national component of INTERPHONE Study

The first results of analyses of risk of acoustic neurinoma risk in relation to use of mobile telephones in the Danish part of INTERPHONE were published on 27 January 2004 in the American Journal of Epidemiology Helle Collatz Christensen, Joachim Schüz, Michael Kosteljanetz, Hans Skovgaard Poulsen, Jens Thomsen, and Christoffer Johansen Cellular Telephone Use and Risk of Acoustic Neuroma, Am. J. Epidemiol. 2004 159: 277-283 (

The study included 106 cases of incident acoustic neurinoma cases in Denmark diagnosed in 2000-2002 and 212 controls, matched on sex and age. No association was seen between regular mobile phone use and risk of this disease (OR=0.9, 95% CI 0.5-1.6). The average size of tumours was significantly higher, however, for regular users than for non-users (1.66 cm3 vs. 1.39, p=0.03).

Analyses of laterality of phone use indicated significant disagreement between side of use of the phone and the side of the head where the tumour developed. The authors discuss the possibility that hearing loss may be a negative confounder of the association between mobile phone use and acoustic neurinoma risk, as the presence of hearing problems prior to diagnosis may prevent cases from becoming regular users, limit their lifetime calling time and/or force them to switch the side of their head on which they hold the phone when they use.

Results of other national components of the INTERPHONE Study should be published later in 2004, and the first paper from the International analyses in late 2004 or early 2005.

More information about the Danish study and its results can be found on the site of the Danish Cancer Centre The press release in Danish is available at: